MovDisordV3, Main, Exploration, bibRecord, 000460

Prospective study of obesity, hypertension, high cholesterol and risk of Restless Legs Syndrome

Identifieur interne : 000460 ( Main/Exploration ); précédent : 000459; suivant : 000461

Prospective study of obesity, hypertension, high cholesterol and risk of Restless Legs Syndrome

Auteurs : Katerina De Vito ; Yanping Li ; Salma Batool-Anwar ; Yi Ning ; Jiali Han ; Xiang Gao [République populaire de Chine]

Source :

Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2014.

RBID : PMC:4501395

English descriptors

KwdEn :
- Adult, Age Factors, Blood Pressure, Body Mass Index, Cholesterol (blood), Cohort Studies, Female, Humans, Hypertension (epidemiology), Male, Middle Aged, Obesity (blood), Obesity (diagnosis), Obesity (epidemiology), Restless Legs Syndrome (epidemiology), Sex Factors, Waist Circumference.
MESH :
- chemical , blood : Cholesterol.
- blood : Obesity.
- diagnosis : Obesity.
- epidemiology : Hypertension, Obesity, Restless Legs Syndrome.
- Adult, Age Factors, Blood Pressure, Body Mass Index, Cohort Studies, Female, Humans, Male, Middle Aged, Sex Factors, Waist Circumference.

Abstract

Background

Because previous cross-sectional studies suggest an association between metabolic disorders and Restless Legs Syndrome (RLS), we prospectively evaluated whether obesity, hypercholesterolemia, and hypertension were associated with increased risk of RLS.

Methods

Our study consisted of 42728 female participants from the Nurses’ Health Study II and 12812 male participants from the Health Professionals Follow-up Study, free of RLS at baseline (2002 for men and 2005 for women), and free of diabetes and arthritis through follow-up (2002–2008 for men and 2005–2009 for women). RLS symptoms were assessed using the International RLS Study Group’s standardized questionnaire. We considered RLS symptoms a “case” if the symptoms occurred ≥5 times/month and met International RLS Study Group criteria.

Results

We found that obesity was associated with an increased risk RLS among both men and women (P-difference for sex >0.5). The pooled multivariate-adjusted odds ratio (OR) for RLS was 1.57 (95% confidence interval (CI): 1.33–1.85; P-trend <0.0001) for body mass index >30kg/m² vs ≤23kg/m², and 1.56 (95%CI: 1.29–1.89; P-trend=0.0001) comparing two extreme waist circumference quintiles, adjusting for age, ethnicity, smoking, physical activity, use of antidepressant, and other covariates. A similar significant association was found for high cholesterol; the pooled adjusted OR for total serum cholesterol >240mg/dL vs. <159mg/dL was 1.33 (95%CI: 1.11–1.60; P-trend=0.002). There was no significant association between hypertension and RLS risk (Adjusted OR=0.90, 95% CI: 0.79–1.02).

Conclusions

In this large prospective study we found that obesity and high cholesterol, but not high blood pressure, were significantly associated with an increased risk of developing RLS.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4501395

DOI: 10.1002/mds.25860
PubMed: 24753235
PubMed Central: 4501395

Affiliations:

Le document en format XML

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<author><name sortKey="De Vito, Katerina" sort="De Vito, Katerina" uniqKey="De Vito K" first="Katerina" last="De Vito">Katerina De Vito</name>
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<term>Cohort Studies</term>
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<term>Humans</term>
<term>Hypertension (epidemiology)</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Obesity (blood)</term>
<term>Obesity (diagnosis)</term>
<term>Obesity (epidemiology)</term>
<term>Restless Legs Syndrome (epidemiology)</term>
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<term>Waist Circumference</term>
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<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Obesity</term>
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<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Hypertension</term>
<term>Obesity</term>
<term>Restless Legs Syndrome</term>
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<term>Age Factors</term>
<term>Blood Pressure</term>
<term>Body Mass Index</term>
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<front><div type="abstract" xml:lang="en"><sec id="S1"><title>Background</title>
<p id="P1">Because previous cross-sectional studies suggest an association between metabolic disorders and Restless Legs Syndrome (RLS), we prospectively evaluated whether obesity, hypercholesterolemia, and hypertension were associated with increased risk of RLS.</p>
</sec>
<sec id="S2"><title>Methods</title>
<p id="P2">Our study consisted of 42728 female participants from the Nurses’ Health Study II and 12812 male participants from the Health Professionals Follow-up Study, free of RLS at baseline (2002 for men and 2005 for women), and free of diabetes and arthritis through follow-up (2002–2008 for men and 2005–2009 for women). RLS symptoms were assessed using the International RLS Study Group’s standardized questionnaire. We considered RLS symptoms a “case” if the symptoms occurred ≥5 times/month and met International RLS Study Group criteria.</p>
</sec>
<sec id="S3"><title>Results</title>
<p id="P3">We found that obesity was associated with an increased risk RLS among both men and women (P-difference for sex >0.5). The pooled multivariate-adjusted odds ratio (OR) for RLS was 1.57 (95% confidence interval (CI): 1.33–1.85; P-trend <0.0001) for body mass index >30kg/m<sup>2</sup>
 vs ≤23kg/m<sup>2</sup>
, and 1.56 (95%CI: 1.29–1.89; P-trend=0.0001) comparing two extreme waist circumference quintiles, adjusting for age, ethnicity, smoking, physical activity, use of antidepressant, and other covariates. A similar significant association was found for high cholesterol; the pooled adjusted OR for total serum cholesterol >240mg/dL vs. <159mg/dL was 1.33 (95%CI: 1.11–1.60; P-trend=0.002). There was no significant association between hypertension and RLS risk (Adjusted OR=0.90, 95% CI: 0.79–1.02).</p>
</sec>
<sec id="S4"><title>Conclusions</title>
<p id="P4">In this large prospective study we found that obesity and high cholesterol, but not high blood pressure, were significantly associated with an increased risk of developing RLS.</p>
</sec>
</div>
</front>
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<affiliations><list><country><li>République populaire de Chine</li>
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<tree><noCountry><name sortKey="Batool Anwar, Salma" sort="Batool Anwar, Salma" uniqKey="Batool Anwar S" first="Salma" last="Batool-Anwar">Salma Batool-Anwar</name>
<name sortKey="De Vito, Katerina" sort="De Vito, Katerina" uniqKey="De Vito K" first="Katerina" last="De Vito">Katerina De Vito</name>
<name sortKey="Han, Jiali" sort="Han, Jiali" uniqKey="Han J" first="Jiali" last="Han">Jiali Han</name>
<name sortKey="Li, Yanping" sort="Li, Yanping" uniqKey="Li Y" first="Yanping" last="Li">Yanping Li</name>
<name sortKey="Ning, Yi" sort="Ning, Yi" uniqKey="Ning Y" first="Yi" last="Ning">Yi Ning</name>
</noCountry>
<country name="République populaire de Chine"><noRegion><name sortKey="Gao, Xiang" sort="Gao, Xiang" uniqKey="Gao X" first="Xiang" last="Gao">Xiang Gao</name>
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</record>

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Movement Disorders (revue)

Prospective study of obesity, hypertension, high cholesterol and risk of Restless Legs Syndrome

Prospective study of obesity, hypertension, high cholesterol and risk of Restless Legs Syndrome

Source :

English descriptors

Abstract

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Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

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Pour générer des pages wiki

	Movement Disorders (revue)
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